Mechanism of Action
Senshio is the first oral, tissue-selective treatment for VVA that does not contain hormones.4, 6-10 It is a SERM (selective oestrogen receptor modulator) with proven effects in the vagina.4, 9 Senshio addresses the underlying cause of VVA, helping to reduce the symptoms of VVA.3,11-14
Senshio Safety Profile
The safety of Senshio has been assessed in over 1,100 women with VVA in phase II/III trials4
Who is Sensio For?
Symptoms of VVA can negatively affect many areas of a woman's life, impacting her everyday life and impairing the quality of her sex life and relationships.15-17
Senshio is indicated for menopausal women with with moderate to severe symptomatic VVA.4
Senshio Efficacy
Senshio significantly improves symptoms of vaginal dryness and dyspareunia in a majority of women by 12 weeks vs. placebo. 4,11
Senshio in Summary
Senshio is the first oral prescription treatment that does not contain hormones, for the treatment of women with symptomatic VVA4-6
References:
- Neves-e-Castro M, et al. Maturitas 2015; 81(1): 88–92.
- Stuenkel C, et al. JCEM 2015; 100(11): 3975–4011.
- Palacios S, Cancelo M. International Journal of Women’s Health 2016; 8: 617–626.
- Senshio Summary of Product Characteristics.
- Menopause: diagnosis and management. NICE guideline [NG23] November 2015. https://www.nice.org.uk/guidance/ng23/resources/menopause-diagnosis-andmanagement-pdf-1837330217413 [Accessed June 2024].
- Portman D, et al. Maturitas 2014; 78: 91–98.
- Kangas L and Unkila M. Steroids 2013; 78(12): 1273-1280.
- Pinkerton J and Thomas S. J Steroid Biochem Mol Biol 2014; 142: 142-154.
- Del Pup L. Eur Rev Med Pharmacol Sci. 2016; 20(18): 3934-44.
- Pérez L. Rev Esp Reumatol 2004; 31(1): 13-7.
- Bachmann G, et al. Menopause 2010; 17: 480-486.
- Cancelo M, et al. Prog Obstet Ginecol 2016; 59(3): 141-150.
- Alvisi A, et al. Gynecological Endocrinology 2017; 31: 1-5.
- Nappi R, et al. Climacteric 2015; 18: 233-240.
- Nappi R and Kokot-Kierepa M. Climacteric 2012; 15: 36-44.
- Nappi R, et al. Maturitas 2013; 75: 373-379.
- Kingsberg S, et al. J Sex Med 2013; 10(7): 1790–1799.